References & Publications


We have received attention in both news and medical publications.  Here is an updated list of those publications.

  1. Corneal Collagen Cross Linking
    file (514.21 KB)
    Mazen M. Sinjab Arthur B. Cummings Editors
  2. Corneal crosslinking without epithelial removal
    file (730.80 KB)
    R. Doyle Stulting, MD, PhD, William B. Trattler, MD, Jonathan M. Woolfson, MD, Roy S. Rubinfeld, MD, MA
  3. Quantitative analysis of corneal stromal riboflavin concentration without epithelial removal
    file (1.03 MB)
    Roy S. Rubinfeld, MD, MA, R. Doyle Stulting, MD, PhD, Glenwood G. Gum, MS, PhD, Jonathan H. Talamo, MD
  4. Is this the end of the Epi-On vs. Epi-Off debate? The latest from the International CXL Congress
    file (1.38 MB)
    Roy Rubinfeld, MA, MD,  Jonathan Talamo, MD, Doyle Stulting, MD, PhD
  5. Point-Counterpoint debate addressing the question of Epi-On vs. Off CXL
    file (1.63 MB)
    Cosimo Mazzotta, MD, PHD and Roy Rubinfeld, MD, MA - Cataract and Refractive Surgery Today 2017
  6. EpiSmartTM Epi-On CXL procedure stops vision loss when standard Epi-Off CXL fails
    file (2.20 MB)
    Roy S. Rubinfeld, MD, Rachel H. Epstein, MD, Parag A. Majmudar, MD, Deborah Kim, OD, Michael Choi, BS, Randy J. Epstein, MD - Journal of Cataract and Refractive Surgery, 2017
  7. What are the advantages of epi-on vs. off corneal crosslinking?
    file (157.57 KB)
    Roy Rubinfeld, MD
  8. Why I Chose to Perform a New Procedure on a Loved One
    file (344.90 KB)
    William B. Trattler, MD - Cataract & Refractive Surgery Today Europe February 2014
  9. Cross-Linking - Finding The Right Parameters
    file (128.59 KB)
    Christopher Kent - Review of Ophthalmology September 2015
  10. LASIK Combined with Corneal Cross-linking in Eyes with Potentially Elevated Risk of Corneal Ectasia
    file (718.50 KB)
    Michael Korchak, MD; Roxanne Littner, MS; Briana E. McFadden, MHA; MS; Tonoa Person, COT; William Trattler, MD; Roy Rubinfeld, MD
  11. Combining CXL and CK
    file (500.94 KB)
  12. One surgeon’s impressions after 2 years of cross-linking experience
    file (3.49 MB) - Ocular Surgery News
  13. Cross-linking round table part 2 Epi-on vs. epi-off and measures of success
    file (2.08 MB) Ocular Surgery News
  14. Cross-linking round table part 1 Controversies techniques and treatment decisions
    file (1.57 MB) Ocular Surgery News
  15. Learning process ongoing for corneal collagen cross-linking
    file (2.47 MB) Ocular Surgery News
  16. Applications advances in cross-linking offer treatment opportunities for variety of patients
    file (167.06 KB)
    Richard L. Lindstrom, MD
  17. Researchers attempt to progress cross-linking in the US
    file (350.74 KB)
    Ocular Surgery News
  18. Peripheral Sterile Corneal Infiltrates and Melting After Collagen Crosslinking for Keratoconus
    file (228.58 KB)
    Angunawela, R. I., MRCOphth; Arnalich-Montiel, F., PhD, MD; Allan, B. D.S, MD, FRCOphth
  19. Transepithelial CXL Is Gaining Ground
    file (683.77 KB)
    Rubinfeld, R. S.
  20. Patient Example
    file (404.94 KB)
    Rubinfeld, R. S.
  21. Corneoplastics Emerging as the Newest Frontier...
    file (47.71 KB)
    Alio, Jorge
  22. UVA-light and Riboflavin-mediated Corneal Collagen Cross-linking
    file (123.19 KB)
    Erik Letko, MD Parag A. Majmudar, MD S. Lance Forstot, MD Randy J. Epstein, MD Roy S. Rubinfeld, MD
  23. Epithelial-on Crosslinking Shows Promise
    file (185.48 KB)
    Michelle Dalton
  24. Epi-On or Epi-Off Only Time Will Tell
    file (96.59 KB)
    Linda Roach
  25. Washington Post-Preparation for surgery revealed cause of deteriorating eyesight
    file (526.79 KB)
    Sandra G. Boodman
  26. Cross-Linking: Asking the Tough Questions
    file (329.39 KB)
    Christopher Kent
  27. iSite Newsletter 2011
    file (296.86 KB)
    Eef van der Worp
  28. The Promise of Corneal Collagen Cross-Linking
    file (81.97 KB)
    W. Trattler, P. Majmudar, R. Rubinfeld. S. Feldman
  29. The Future of Corneal Cross-Linking
    file (334.37 KB)
    A. Cummings, S. Daya, G. Kanellopoulos, A. Leccisotti, M. Mrochen, R. Rubinfeld, T. Seiler, A. Stojanivic, W. Trattler
  30. Answering Your Patients’ Questions About Cross-Linking
    file (145.17 KB)
  31. High Astigmatism After PKP
    file (118.60 KB)


Information on this page was gathered from a variety of sources.  They are listed below. 

  • Wollensak G, Spoerl E, Seiler T.; Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. AJO 2003 May;135(5):620-7
  • Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE.; Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg. 2008 May;34(5):796-801.
  • Coskunseven E, Jankov MR 2nd, Hafezi F.; Contralateral eye study of corneal collagen cross-linking with riboflavin and UVA irradiation in patients with keratoconus. J Refract Surg. 2009 Apr;25(4):371-376
  • Grewal DS, Brar GS, Jain R, Sood V, Singla M, Grewal SP.; Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. J Cataract Refract Surg. 2009 Mar;35(3):425-32.
  • Spoerl E, Mrochen M, Sliney D, Trokel S, Seiler T.; Safety of UVA-riboflavin cross-linking of the cornea. Cornea. 2007 May;26(4):385-9.Trattler W, Rubinfeld R, Corneal Collagen Cross-linking; Cataract and Refractive Surgery Today; September 2009
  • Caporossi A, Mazzotta C, Baiocchi S, Caporossi T. Long-term Results of Riboflavin Ultraviolet A Corneal Collagen Cross-linking for Keratoconus in Italy: The Siena Eye Study. Am Journal of Ophthalmology 2010:149:585-593
  • Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cat Ref Surg. 2008
  • Vinciguerra P, Albè E, Trazza S, Seiler T, Epstein D. Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. Arch Ophth. 2009 
  • Daley, R. Cornea
Cross-linking vision improvement evidence mounts. Eyeworld, 2010. 
  • Rubinfeld RS, Trattler WB, Martin NF, Adi MA and The CXL-USA Study Group: Answering Your Patients’ Questions About Cross-Linking; Advanced Ocular Care. March 2010:25-28 
  • Boxer Wachler BS, Pinelli R, Ertan A, Colin CKC. Safety and efficacy of transepithelial crosslinking (C3-R/CXL), J CATARACT REFRACT SURG - VOL 36, Pgs 186-187, JANUARY 2009
  • Pinelli R, El Beltagi T, Leccisotti A. Update on Corneal Crosslinking. Cataract and Refractive Surgery Today October 2008: 67-69.

Transepithelial (epithelium –on) corneal crosslinking is an investigational procedure in the US, and the medical device associated with this procedure is limited by Federal law to investigational use.