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Quantitative Analysis of Corneal Stromal Riboflavin Concentration Without Epithelial Removal


Roy Rubinfeld, MD, MA; R. Doyle Stulting, MD; Glenwood Gum, PhD; and Jonathan Talamo, MD

Conclusion: [Effective novel system gets riboflavin into cornea without removing epithelium.] The test transepithelial [epithelium-on EpiSmart] CXL system achieved corneal stromal concentrations of riboflavin that were… adequate for effective CXL… [and other riboflavin formulation was not].

View the original slides presented at the International CXL Congress in Boston, MA: “Is this the end of the epithelium-on vs. epithelium-off debate? A quantitative analysis reveals trans-epithelial corneal riboflavin loading in epithelium-on CXL.”